Karolinska Development’s portfolio company, Aprea Therapeutics, a privately held, clinical stage biopharmaceutical company developing novel anticancer therapies targeting the tumour suppressor protein p53, has announced a collaboration with Memorial Sloan Kettering Cancer Center to study the effects of reactivation of tumour suppressor protein p53 by APR-246.
The goal of the collaboration is to evaluate and characterise the preclinical efficacy of APR-246 in combination with multiple other anticancer agents and across multiple tumour types.
The Principal Investigator of the study is Taha Merghoub, PhD, and he will be conducting the research in collaboration with the laboratory of Jedd D. Wolchok, MD, PhD, Chief of Melanoma and Immunotherapeutics Service, Department of Medicine.
“We are excited to initiate this new collaboration with Memorial Sloan Kettering,” said Christian S. Schade, President and Chief Executive Officer of Aprea Therapeutics AB. “These studies will not only provide important insight into the effects of APR-246-induced p53 reactivation but also inform the rationale for novel combination therapies to be tested in future clinical trials.”